using chaotic advection for facile high-throughput

A Microfluidic System for Controlling Reaction Networks

Chaotic advection accelerates mixing by using unsteady fluid flow to stretch and fold a volume of fluid. Stretching and folding leads to a rapid, exponential decrease of the striation length—distance over which mixing has to occur by diffusion.

Towards better DNA chip hybridization using chaotic

Numerical studies for two protocols of micromixing based on chaotic advection to improve DNA chip hybridization are presented. The first protocol uses syringes; the other one, pumps. For both protocols, numerical Poincar sections and Lyapunov exponents of the

Springer

For chaotic advection, different implementations tailor-made for low and comparatively high Reynolds numbers exist, both leading to an exponential increase of the interface between two fluids. Split-and-recombine flows can only be realized in a close-to-ideal form in the low Reynolds number regime.

Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels

Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels Helen Song, Michelle R. Bringer, Joshua D. Tice, Cory J. Gerdts, and Rustem F. Ismagilova) Department of Chemistry, The University of Chicago, 5735 S

Using Chaos for Facile High

This paper introduces the concept of continuous chaotic printing, i.e., the use of chaotic flows for deterministic and continuous fabrication of fibers with internal multilayered micro-or nanostructures. Two free-flowing materials are coextruded through a printhead containing a miniaturized Kenics static mixer (KSM) composed of multiple helicoidal elements. This produces a fiber with a well

Rapid microfluidic mixing allows intelligent biocatalyst

Microfluidic system extracts kinetics and thermodynamics of complex enzymatic reactions in high-throughput have developed a droplet-based microfluidic platform that overcomes the aforementioned limitations, by leveraging chaotic advection, coupled to

Towards better DNA chip hybridization using chaotic

Numerical studies for two protocols of micromixing based on chaotic advection to improve DNA chip hybridization are presented. The first protocol uses syringes; the other one, pumps. For both protocols, numerical Poincar sections and Lyapunov exponents of the

High

In this study, a mini hydrodynamic focusing device with two feedback channels was designed to produce droplets of two immiscible liquids with a high throughput. Compared to conventional hydrodynamic focusing devices, the design can prevent the two liquids from forming parallel flows that suppress the dispersed phase from breaking up into droplets with high throughputs. A red aqueous solution

Microfluidic

41 this case propofol). The setup, based on a chaotic advection micromixer, showed 42 high drug loading (41 mol%) of propofol as well as the ability to manufacture 43 vesicles with at prescribed sizes (between 50 to 450 nm) in a high‐throughput 44 setting. Our results demonstrate the

Angewandte Chemie Communications

forming plugs of multiple solutions of reagents, for using chaotic advection to achieve especially rapid (~2ms)mixing within the plugs, and for splitting and merging these plugs in order to create complex microfluidic networks. To form droplets from two solutions of

Rev. Mod. Phys. 89, 025007 (2017)

The physics of chaotic advection is a field that emerged at the intersection of nonlinear dynamics and fluid mechanics. An older term for the field is Langrangian turbulence. This review deals with mathematical physics descriptions and perspectives of chaotic features in transport and mixing in fluid systems of sizes ranging from micrometers to hundreds of kilometers.

Exploring mechanism of enzyme catalysis by on

When using segmented flows, reagent mixing can be passively accelerated through chaotic advection induced by geometric turns along the flow path.26 Using such an approach, we developed a microfluidic platform that rapidly accelerates droplets shortly after

Chaotic mixing in microfluidic devices driven by oscillatory

chaotic mixing in microfluidic devices for both confined and continuous throughput flow configurations. The flow is analyzed using numerical simulation of the unsteady Navier–Stokes equations combined with tracking of single and multispecies passive tracer

Microfluidic

41 this case propofol). The setup, based on a chaotic advection micromixer, showed 42 high drug loading (41 mol%) of propofol as well as the ability to manufacture 43 vesicles with at prescribed sizes (between 50 to 450 nm) in a high‐throughput 44 setting. Our results demonstrate the

Chaotic mixing in a bounded three

Chaotic mixing in a bounded three-dimensional flow - Volume 417 - G. O. FOUNTAIN, D. V. KHAKHAR, I. MEZIĆ, J. M. OTTINO Even though the first theoretical example of chaotic advection was a three-dimensional flow (Hnon 1966), the number of theoretical

Approval Notification of 2017 Research Fund for International Young Scientists

High-throughput Biochip for Characterization of Microalgae Culture Conditions Jaewon Park 46 3171101059 Quantitative Analysis of Urea/Glucose in Healthy and Sick Peoples (Urine and Blood) Using Chitosan and Magnetic Nanoparticles for 47

3D bioprinting using chaotic flows

Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro-and nanostructures: continuous chaotic printing. Biofabrication. 12 035023. Trujillo-de Santiago G, Alvarez MM, Samandari M, Prakash G, Chandrabhatla G, Rellstab-Snchez PI, Byambaa B, Abadi PPSS, Mandla S, Avery RK, Vallejo-Arroyo A, Nasajpour A, Annabi N, Zhang YS, Khademhosseini A (2018).

The Use of an Efficient Microfluidic Mixing System for

This microfluidics system allows high throughput and is scalable for the efficient preparation of PLGA nanoparticles and PEGylated PLGA nanoparticles. Our results will be useful for developing novel PLGA-based polymer nanoparticles by using the microfluidics.

3D bioprinting using chaotic flows

Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro-and nanostructures: continuous chaotic printing. Biofabrication. 12 035023. Trujillo-de Santiago G, Alvarez MM, Samandari M, Prakash G, Chandrabhatla G, Rellstab-Snchez PI, Byambaa B, Abadi PPSS, Mandla S, Avery RK, Vallejo-Arroyo A, Nasajpour A, Annabi N, Zhang YS, Khademhosseini A (2018).

Exploring mechanism of enzyme catalysis by on

When using segmented flows, reagent mixing can be passively accelerated through chaotic advection induced by geometric turns along the flow path.26 Using such an approach, we developed a microfluidic platform that rapidly accelerates droplets shortly after

Chaotic mixing in a bounded three

Chaotic mixing in a bounded three-dimensional flow - Volume 417 - G. O. FOUNTAIN, D. V. KHAKHAR, I. MEZIĆ, J. M. OTTINO Even though the first theoretical example of chaotic advection was a three-dimensional flow (Hnon 1966), the number of theoretical

Microfluidic

41 this case propofol). The setup, based on a chaotic advection micromixer, showed 42 high drug loading (41 mol%) of propofol as well as the ability to manufacture 43 vesicles with at prescribed sizes (between 50 to 450 nm) in a high‐throughput 44 setting. Our results demonstrate the

Towards better DNA chip hybridization using chaotic

Numerical studies for two protocols of micromixing based on chaotic advection to improve DNA chip hybridization are presented. The first protocol uses syringes; the other one, pumps. For both protocols, numerical Poincar sections and Lyapunov exponents of the

Continuous chaotic bioprinting of skeletal muscle

2021/3/1Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro- and nanostructures: continuous chaotic printing Biofabrication, 12 (2020), Article 035023, 10.1088/1758-5090/ab84cc CrossRef View Record in Scopus Google Scholar D.M.

Experimental test of scaling of mixing by chaotic

2003/12/1Chaotic advection was observed to accelerate mixing the most for systems with high Pclet number: for wide channels, high flow velocities, and analytes with low diffusion coefficients. Submillisecond mixing (as rapid as ∼500 μ s) has been obtained with this system [ Fig. 2(b) ].

Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels

Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels Helen Song, Michelle R. Bringer, Joshua D. Tice, Cory J. Gerdts, and Rustem F. Ismagilova) Department of Chemistry, The University of Chicago, 5735 S

Experimental test of scaling of mixing by chaotic

2003/12/1Chaotic advection was observed to accelerate mixing the most for systems with high Pclet number: for wide channels, high flow velocities, and analytes with low diffusion coefficients. Submillisecond mixing (as rapid as ∼500 μ s) has been obtained with this system [ Fig. 2(b) ].

High‐throughput droplet‐based microfluidics for directed

High‐throughput screening is a poorly defined term, but is generally understood to describe platforms and methods able to perform between 10 4 and 10 5 tests per day 17. Based on this definition, methods able to screen more than 10 6 compounds per day can be considered as ultra‐high‐throughput.

Approval Notification of 2017 Research Fund for International Young Scientists

High-throughput Biochip for Characterization of Microalgae Culture Conditions Jaewon Park 46 3171101059 Quantitative Analysis of Urea/Glucose in Healthy and Sick Peoples (Urine and Blood) Using Chitosan and Magnetic Nanoparticles for 47

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